Synthesis, Characterization, Molecular Docking and Biological studies on Novel Pyazole fused Indole Derivatives

The present work deals with the sequence of Novel Pyrazole fused Indole derivatives(4a-4l) were synthesized by simple conventional method andscreened for anthelmintic, antibacterial and anticancer activities. molecular docking studies also performed. All newly synthesizedcompounds structurally characterized on basis IR, 1HNMR Mass spectral analysis. Further, all prepared pyrazole fusedindole derivatives screened anthelmintic activity using Albendazole as standard drug. was carried out agardiffusion (Cup plate) Streptomycin against MCF-7 cell lines MTT assay method. resultsshowed that some compounds 4b, 4c 4f exhibited good activity. 4c, 4f, 4j showed and4b,4h 4i potential comparing Additionally, novel pyrazolefused to explain putative bonding interaction between active site EGFR enzyme NovelPyrazole Schrodinger suite.